Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand
Joint Authors
Le Roux, Emilie
Navas, Maria-Cristina
Karalak, Anant
Villar, Stéphanie
Sangrajrang, Suleeporn
Vieco, Beatriz
Srivatanakul, Petcharin
Suarez, Iris
Chemin, Isabelle
Le Calvez-Kelm, Florence
Hainaut, Pierre
Trépo, Christian
Galy, Olivier
Chevallier, Michèle
Gouas, Doriane
Lereau, Myriam
Norder, Heléne
Source
Hepatitis Research and Treatment
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) may develop according to two major pathways, one involving HBV infection and TP53 mutation and the other characterized by HCV infection and CTNNB1 mutation.
We have investigated HBV/HCV infections and TP53/CTNNB1 mutations in 26 HCC patients from Thailand.
HBV DNA (genotype B or C) was detected in 19 (73%) of the cases, including 5 occult infections and 3 coinfections with HCV.
TP53 and CTNNB1 mutations were not mutually exclusive, and most of TP53 mutations were R249S, suggesting a significant impact of aflatoxin-induced mutagenesis in HCC development.
American Psychological Association (APA)
Galy, Olivier& Chemin, Isabelle& Le Roux, Emilie& Villar, Stéphanie& Le Calvez-Kelm, Florence& Lereau, Myriam…[et al.]. 2011. Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand. Hepatitis Research and Treatment،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-491418
Modern Language Association (MLA)
Galy, Olivier…[et al.]. Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand. Hepatitis Research and Treatment No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-491418
American Medical Association (AMA)
Galy, Olivier& Chemin, Isabelle& Le Roux, Emilie& Villar, Stéphanie& Le Calvez-Kelm, Florence& Lereau, Myriam…[et al.]. Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand. Hepatitis Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-491418
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491418
