Properties and Biocompatibility of Chitosan and Silk Fibroin Blend Films for Application in Skin Tissue Engineering
Joint Authors
Luangbudnark, Witoo
Surakunprapha, Palakorn
Laupattarakasem, Pisamai
Viyoch, Jarupa
Laupattarakasem, Wiroon
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Chitosan/silk fibroin (CS/SF) blend films were prepared and evaluated for feasibility of using the films as biomaterial for skin tissue engineering application.
Fourier transform infrared spectroscopy and differential scanning calorimetry analysis indicated chemical interaction between chitosan and fibroin.
Chitosan enhanced β-sheet conformation of fibroin and resulted in shifting of thermal degradation of the films.
Flexibility, swelling index, and enzyme degradation were also increased by the chitosan content of the blend films.
Biocompatibility of the blend films was determined by cultivation with fibroblast cells.
All films showed no cytotoxicity by XTT assay.
Fibroblast cells spread on CS/SF films via dendritic extensions, and cell-cell interactions were noted.
Cell proliferation on CS/SF films was also demonstrated, and their phenotype was examined by the expression of collagen type I gene.
These results showed possibility of using the CS/SF films as a supporting material for further study on skin tissue engineering.
American Psychological Association (APA)
Luangbudnark, Witoo& Viyoch, Jarupa& Laupattarakasem, Wiroon& Surakunprapha, Palakorn& Laupattarakasem, Pisamai. 2012. Properties and Biocompatibility of Chitosan and Silk Fibroin Blend Films for Application in Skin Tissue Engineering. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-491421
Modern Language Association (MLA)
Luangbudnark, Witoo…[et al.]. Properties and Biocompatibility of Chitosan and Silk Fibroin Blend Films for Application in Skin Tissue Engineering. The Scientific World Journal No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-491421
American Medical Association (AMA)
Luangbudnark, Witoo& Viyoch, Jarupa& Laupattarakasem, Wiroon& Surakunprapha, Palakorn& Laupattarakasem, Pisamai. Properties and Biocompatibility of Chitosan and Silk Fibroin Blend Films for Application in Skin Tissue Engineering. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-491421
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491421