Titrimetric and Spectrophotometric Methods for the Assay of Ketotifen Using Cerium(IV) and Two Reagents
Joint Authors
Vinay, Kanakapura Basavaiah
Raghu, Madihalli Srinivas
Prashanth, Kudige Nagaraj
Basavaiah, Kanakapura
Source
International Journal of Analytical Chemistry
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
One titrimetric and two spectrophotometric methods are described for the determination of ketotifen fumarate (KTF) in bulk drug and in tablets using cerium(IV) as the oxidimetric agent.
In titrimetry (method A), the drug was treated with a measured excess of cerium(IV) in H2SO4 medium and after a standing time of 10 min, the surplus oxidant was determined by back titration with iron(II).
The spectrophotometric procedures involve addition of a known excess of cerium(IV) to KTF in acid medium followed by the determination of unreacted oxidant by reacting with either p-dimethyl amino benzaldehyde and measuring the resulting colour at 460 nm (method B) or o-dianisidine and subsequent measurement of the absorbance of coloured product at 470 nm (method C).
Titrimetric assay is based on a 1 : 2 reaction stoichiometry between KTF and cerium(IV) and the method is applicable over 2–18 mg range.
In spectrophotometry, regression analysis of Beer’s law plots showed a good correlation in 0.4–8.0 and 0.4–10.0 g mL−1 KTF ranges for method B and method C, respectively, and the corresponding molar absorptivity coefficients are calculated to be 4.0×104 and 3.7×104 L mol−1 cm−1.
American Psychological Association (APA)
Raghu, Madihalli Srinivas& Basavaiah, Kanakapura& Prashanth, Kudige Nagaraj& Vinay, Kanakapura Basavaiah. 2013. Titrimetric and Spectrophotometric Methods for the Assay of Ketotifen Using Cerium(IV) and Two Reagents. International Journal of Analytical Chemistry،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-491465
Modern Language Association (MLA)
Raghu, Madihalli Srinivas…[et al.]. Titrimetric and Spectrophotometric Methods for the Assay of Ketotifen Using Cerium(IV) and Two Reagents. International Journal of Analytical Chemistry No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-491465
American Medical Association (AMA)
Raghu, Madihalli Srinivas& Basavaiah, Kanakapura& Prashanth, Kudige Nagaraj& Vinay, Kanakapura Basavaiah. Titrimetric and Spectrophotometric Methods for the Assay of Ketotifen Using Cerium(IV) and Two Reagents. International Journal of Analytical Chemistry. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-491465
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491465