Antioxidant and Anti-Cancer Potentials of Rheum emodi Rhizome Extracts
Joint Authors
Rajkumar, Venkatadri
Guha, Gunjan
Ashok Kumar, Rangasamy
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The objective of this study was to determine antioxidant and cytotoxic efficacies of methanolic and aqueous extracts of Rheum emodi Wall.
ex Meissn.
rhizome.
2,2-Diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radical scavenging activities, inhibitory effect on lipid peroxidation and Fe3+ reducing antioxidant property have been used to investigate antioxidant properties of the extracts.
Cytotoxicity of the extracts was tested on MDA-MB-435S and Hep3B cell lines.
Both extracts displayed extensive cytotoxicity to the tested cell lines.
The extracts were studied for their ability to protect pBR322 DNA from damage by UV induced photolysis of H2O2.
The aqueous extract, though inferior to methanolic extract in its antioxidant potential exhibited efficiency in DNA protection, while the methanolic extract failed to protect the DNA.
The amount of total polyphenolics in the extracts was measured by spectrophotometric method.
The methanolic extract contained higher polyphenolic contents than aqueous extract.
Significant positive correlations were observed (P < .05) between results of phenolic content estimation and that of antioxidant assays.
Hence, high-performance liquid chromatography analysis was performed to identify few major phenolic compounds that might be responsible for these therapeutic properties.
These results indicate that rhizome of R.
emodi possesses antioxidant and cytotoxic activities and therefore have therapeutic potential.
American Psychological Association (APA)
Rajkumar, Venkatadri& Guha, Gunjan& Ashok Kumar, Rangasamy. 2011. Antioxidant and Anti-Cancer Potentials of Rheum emodi Rhizome Extracts. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-491496
Modern Language Association (MLA)
Rajkumar, Venkatadri…[et al.]. Antioxidant and Anti-Cancer Potentials of Rheum emodi Rhizome Extracts. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-491496
American Medical Association (AMA)
Rajkumar, Venkatadri& Guha, Gunjan& Ashok Kumar, Rangasamy. Antioxidant and Anti-Cancer Potentials of Rheum emodi Rhizome Extracts. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-491496
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491496