Interleukin 6 and Rheumatoid Arthritis
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Interleukin-6 (IL-6) is a representative cytokine featuring pleiotropic activity and redundancy.
A transient synthesis of IL-6 contributes to host defense against infectious agents and tissue injuries by inducing acute phase reactions and immunological and hematopoietic responses.
However, uncontrolled persistent production of IL-6 may lead to the development of several immune-mediated diseases.
Rheumatoid arthritis (RA) is a chronic disease with joint and systemic inflammation resulting from immunological abnormalities and it has been found that IL-6 plays a key role in the development of this disease.
Clinical trials in various parts of the world of tocilizumab, a humanized anti-IL-6 receptor antibody, have proved its efficacy and tolerable safety either as monotherapy or in combination with disease-modifying antirheumatic drugs.
As a result, it is currently used as a first-line biologic for the treatment of moderate-to-severe RA in more than 100 countries.
Clarification of the mechanism(s) through which tocilizumab exerts its effect on RA and of the reason(s) why IL-6 is continuously produced in RA can be expected to lead to the best use of this agent for RA patients and aid in investigations into the pathogenesis of RA.
American Psychological Association (APA)
Yoshida, Yuji& Tanaka, Toshio. 2014. Interleukin 6 and Rheumatoid Arthritis. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-491523
Modern Language Association (MLA)
Yoshida, Yuji& Tanaka, Toshio. Interleukin 6 and Rheumatoid Arthritis. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-491523
American Medical Association (AMA)
Yoshida, Yuji& Tanaka, Toshio. Interleukin 6 and Rheumatoid Arthritis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-491523
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491523