Potential Biomarkers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease

Joint Authors

Zaman Huri, Hasniza
Vethakkan, Shireene Ratna
Wan Ahmad, Wan Azman
Syed Ikmal, Sharifah Intan Qhadijah

Source

International Journal of Endocrinology

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-10-24

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Biology

Abstract EN

Type 2 diabetes mellitus patients with coronary artery disease have become a major public health concern.

The occurrence of insulin resistance accompanied with endothelial dysfunction worsens the state of atherosclerosis in type 2 diabetes mellitus patients.

The combination of insulin resistance and endothelial dysfunction leads to coronary artery disease and ischemic heart disease complications.

A recognized biological marker, high-sensitivity C-reactive protein, has been used widely to assess the progression of atherosclerosis and inflammation.

Along with coronary arterial damage and inflammatory processes, high-sensitivity C-reactive protein is considered as an essential atherosclerosis marker in patients with cardiovascular disease, but not as an insulin resistance marker in type 2 diabetes mellitus patients.

A new biological marker that can act as a reliable indicator of both the exact state of insulin resistance and atherosclerosis is required to facilitate optimal health management of diabetic patients.

Malfunctioning of insulin mechanism and endothelial dysfunction leads to innate immune activation and released several biological markers into circulation.

This review examines potential biological markers, YKL-40, alpha-hydroxybutyrate, soluble CD36, leptin, resistin, interleukin-18, retinol binding protein-4, and chemerin, as they may play significant roles in insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease.

American Psychological Association (APA)

Syed Ikmal, Sharifah Intan Qhadijah& Zaman Huri, Hasniza& Vethakkan, Shireene Ratna& Wan Ahmad, Wan Azman. 2013. Potential Biomarkers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-491553

Modern Language Association (MLA)

Syed Ikmal, Sharifah Intan Qhadijah…[et al.]. Potential Biomarkers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease. International Journal of Endocrinology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-491553

American Medical Association (AMA)

Syed Ikmal, Sharifah Intan Qhadijah& Zaman Huri, Hasniza& Vethakkan, Shireene Ratna& Wan Ahmad, Wan Azman. Potential Biomarkers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-491553

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-491553