Bortezomib in Kidney Transplantation
Joint Authors
Achkar, Katafan
Abdellatif, Abdul
Raghavan, Rajeev
Patel, Samir J.
Gaber, A. Osama
Jeroudi, Abdallah
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Although current therapies for pretransplant desensitization and treatment of antibody-mediated rejection (AMR) have had some success, they do not specifically deplete plasma cells that produce antihuman leukocyte antigen (HLA) antibodies.
Bortezomib, a proteasome inhibitor approved for the treatment of multiple myeloma (a plasma cell neoplasm), induces plasma cell apoptosis.
In this paper we review the current body of literature regarding the use of this biological agent in the field of transplantation.
Although limited experience with bortezomib may seem to show promise in the realm of transplant recipients desensitization and treatment of AMR, there is also experience that may suggest otherwise.
Bortezomib's role in desensitization protocols and treatment of AMR will be defined better as more clinical data and trials become available.
American Psychological Association (APA)
Raghavan, Rajeev& Jeroudi, Abdallah& Achkar, Katafan& Gaber, A. Osama& Patel, Samir J.& Abdellatif, Abdul. 2010. Bortezomib in Kidney Transplantation. Journal of Transplantation،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-491557
Modern Language Association (MLA)
Raghavan, Rajeev…[et al.]. Bortezomib in Kidney Transplantation. Journal of Transplantation No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-491557
American Medical Association (AMA)
Raghavan, Rajeev& Jeroudi, Abdallah& Achkar, Katafan& Gaber, A. Osama& Patel, Samir J.& Abdellatif, Abdul. Bortezomib in Kidney Transplantation. Journal of Transplantation. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-491557
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491557