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Human Endogenous Retrovirus W Activity in Cartilage of Osteoarthritis Patients
Joint Authors
Knutsen, Gunnar
Olsen, Randi
Moens, Ugo
Elvenes, Jan
Olsen, Elisabeth
Tümmler, Conny
Bendiksen, Signy
Martinez-Zubiavrra, Inigo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-22
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The etiology of viruses in osteoarthritis remains controversial because the prevalence of viral nucleic acid sequences in peripheral blood or synovial fluid from osteoarthritis patients and that in healthy control subjects are similar.
Until now the presence of virus has not been analyzed in cartilage.
We screened cartilage and chondrocytes from advanced and non-/early osteoarthritis patients for parvovirus B19, herpes simplex virus-1, Epstein Barr virus, cytomegalovirus, human herpes virus-6, hepatitis C virus, and human endogenous retroviruses transcripts.
Endogenous retroviruses transcripts, but none of the other viruses, were detected in 15 out the 17 patients.
Sequencing identified the virus as HERV-WE1 and E2.
HERV-W activity was confirmed by high expression levels of syncytin, dsRNA, virus budding, and the presence of virus-like particles in all advanced osteoarthritis cartilages examined.
Low levels of HERV-WE1, but not E2 envelope RNA, were observed in 3 out of 8 non-/early osteoarthritis patients, while only 3 out of 7 chondrocytes cultures displayed low levels of syncytin, and just one was positive for virus-like particles.
This study demonstrates for the first time activation of HERV-W in cartilage of osteoarthritis patients; however, a causative role for HERV-W in development or deterioration of the disease remains to be proven.
American Psychological Association (APA)
Bendiksen, Signy& Martinez-Zubiavrra, Inigo& Tümmler, Conny& Knutsen, Gunnar& Elvenes, Jan& Olsen, Elisabeth…[et al.]. 2014. Human Endogenous Retrovirus W Activity in Cartilage of Osteoarthritis Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-491560
Modern Language Association (MLA)
Bendiksen, Signy…[et al.]. Human Endogenous Retrovirus W Activity in Cartilage of Osteoarthritis Patients. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-491560
American Medical Association (AMA)
Bendiksen, Signy& Martinez-Zubiavrra, Inigo& Tümmler, Conny& Knutsen, Gunnar& Elvenes, Jan& Olsen, Elisabeth…[et al.]. Human Endogenous Retrovirus W Activity in Cartilage of Osteoarthritis Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-491560
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491560