Effect of Resveratrol on Hematological and Biochemical Alterations in Rats Exposed to Fluoride
Joint Authors
Atmaca, Nurgül
Güner, Bayram
Yıldırım, Ebru
Bilmen, Fatih Sultan
Kabakçı, Ruhi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We investigated the protective effects of resveratrol on hematological and biochemical changes induced by fluoride in rats.
A total of 28 rats were divided into 4 groups: control, resveratrol, fluoride, and fluoride/resveratrol (n=7 each), for a total of 21 days of treatment.
Blood samples were taken and hematological and biochemical parameters were measured.
Compared to the control group, the fluoride-treated group showed significant differences in several hematological parameters, including decreases in WBC, RBC, and PLT counts and neutrophil ratio.
The group that received resveratrol alone showed a decrease in WBC count compared to the control group.
Furthermore, in comparison to the control group, the fluoride group showed significantly increased ALT enzyme activity and decreased inorganic phosphorus level.
The hematological and biochemical parameters in the fluoride + resveratrol treated group were similar to control group.
In the fluoride + resveratrol group, resveratrol restored the changes observed following fluoride treatment, including decreased counts of WBC, RBC, and PLT, decreased neutrophil ratio and inorganic phosphorus levels, and elevated ALT enzyme activity.
The present study showed that fluoride caused adverse effects in rats and that resveratrol reduced hematological and biochemical alterations produced by fluoride exposure.
American Psychological Association (APA)
Atmaca, Nurgül& Yıldırım, Ebru& Güner, Bayram& Kabakçı, Ruhi& Bilmen, Fatih Sultan. 2014. Effect of Resveratrol on Hematological and Biochemical Alterations in Rats Exposed to Fluoride. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-491562
Modern Language Association (MLA)
Atmaca, Nurgül…[et al.]. Effect of Resveratrol on Hematological and Biochemical Alterations in Rats Exposed to Fluoride. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-491562
American Medical Association (AMA)
Atmaca, Nurgül& Yıldırım, Ebru& Güner, Bayram& Kabakçı, Ruhi& Bilmen, Fatih Sultan. Effect of Resveratrol on Hematological and Biochemical Alterations in Rats Exposed to Fluoride. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-491562
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491562