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Dissemination and Molecular Epidemiology of KPC-Producing Klebsiella pneumoniae Collected in Puerto Rico Medical Center Hospitals during a 1-Year Period
Joint Authors
Hanson, Nancy D.
Robledo, Iraida E.
Aquino, Edna E.
Thomson, Kenneth S.
Goering, Richard V.
Vázquez, Guillermo J.
Santé, María I.
Moland, Ellen S.
Source
Epidemiology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
During a 2003-2004 PCR-based surveillance study conducted in 6 Puerto Rico Medical Center hospitals, 27/92 multi-beta-lactam-resistant Klebsiella pneumoniae strains were identified as carbapenemase (KPC) positive in 4 hospitals.
The objectives of this study were to identify the KPC variants, their genetic relatedness, and any other beta-lactamases present.
Susceptibility testing, pulsed field gel electrophoresis (PFGE), isoelectric focusing, PCR, and DNA sequencing were performed.
KPC variants -2, -3, -4, and -6 were identified.
Additional beta-lactamases detected were TEM, DHA, OXA-9 and -30.
Antimicrobial susceptibility to carbapenems varied depending on the KPC variant.
Five PFGE genetically related groups were identified in 15 isolates and 12 unrelated types.
PFGE profiles suggested that both clonal and horizontal transfer are contributing to the dissemination of these isolates among the various hospitals.
Comparison of the 2003 and a 2009 surveillance studies showed a significant increase in the KPC-positive K.
pneumoniae isolates in the latter.
American Psychological Association (APA)
Robledo, Iraida E.& Vázquez, Guillermo J.& Moland, Ellen S.& Aquino, Edna E.& Goering, Richard V.& Thomson, Kenneth S.…[et al.]. 2011. Dissemination and Molecular Epidemiology of KPC-Producing Klebsiella pneumoniae Collected in Puerto Rico Medical Center Hospitals during a 1-Year Period. Epidemiology Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-491568
Modern Language Association (MLA)
Robledo, Iraida E.…[et al.]. Dissemination and Molecular Epidemiology of KPC-Producing Klebsiella pneumoniae Collected in Puerto Rico Medical Center Hospitals during a 1-Year Period. Epidemiology Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-491568
American Medical Association (AMA)
Robledo, Iraida E.& Vázquez, Guillermo J.& Moland, Ellen S.& Aquino, Edna E.& Goering, Richard V.& Thomson, Kenneth S.…[et al.]. Dissemination and Molecular Epidemiology of KPC-Producing Klebsiella pneumoniae Collected in Puerto Rico Medical Center Hospitals during a 1-Year Period. Epidemiology Research International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-491568
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491568