PPARs in the Renal Regulation of Systemic Blood Pressure
Joint Authors
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Recent research has revealed roles for the peroxisome proliferator activated receptor (PPAR) family of transcription factors in blood pressure regulation, expanding the possible therapeutic use of PPAR ligands.
PPARα and PPARγ modulate the renin-angiotensin-aldosterone system (RAAS), a major regulator of systemic blood pressure and interstitial fluid volume by transcriptional control of renin, angiotensinogen, angiotensin converting enzyme (ACE) and angiotensin II receptor 1 (AT-R1).
Blockade of RAAS is an important therapeutic target in hypertension management and attenuates microvascular damage, glomerular inflammation and left ventricular hypertrophy in hypertensive patients and also show antidiabetic effects.
The mechanisms underlying the benefits of RAAS inhibition appear to involve PPARγ-regulated pathways.
This review summarizes current knowledge on the role of PPARs in the transcriptional control of the RAAS and the possible use of PPAR ligands in the treatment of RAAS dependent hypertension.
American Psychological Association (APA)
Rőszer, Tamás& Ricote, Mercedes. 2010. PPARs in the Renal Regulation of Systemic Blood Pressure. PPAR Research،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-491572
Modern Language Association (MLA)
Rőszer, Tamás& Ricote, Mercedes. PPARs in the Renal Regulation of Systemic Blood Pressure. PPAR Research No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-491572
American Medical Association (AMA)
Rőszer, Tamás& Ricote, Mercedes. PPARs in the Renal Regulation of Systemic Blood Pressure. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-491572
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491572