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Pseudoginsenoside F11, a Novel Partial PPARγ Agonist, Promotes Adiponectin Oligomerization and Secretion in 3T3-L1 Adipocytes
Joint Authors
Wang, Pengcheng
Liu, Ling
Wu, Guoyu
Li, Zhen
Yi, Junyang
Zhang, Zhijie
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
PPARγ is a nuclear hormone receptor that functions as a master regulator of adipocyte differentiation and development.
Full PPARγ agonists, such as the thiazolidinediones (TZDs), have been widely used to treat type 2 diabetes.
However, they are characterized by undesirable side effects due to their strong agonist activities.
Pseudoginsenoside F11 (p-F11) is an ocotillol-type ginsenoside isolated from Panax quinquefolium L.
(American ginseng).
In this study, we found that p-F11 activates PPARγ with modest adipogenic activity.
In addition, p-F11 promotes adiponectin oligomerization and secretion in 3T3-L1 adipocytes.
We also found that p-F11 inhibits obesity-linked phosphorylation of PPARγ at Ser-273 by Cdk5.
Therefore, p-F11 is a novel partial PPARγ agonist, which might have the potential to be developed as a new PPARγ-targeted therapeutics for type 2 diabetes.
American Psychological Association (APA)
Wu, Guoyu& Yi, Junyang& Liu, Ling& Wang, Pengcheng& Zhang, Zhijie& Li, Zhen. 2013. Pseudoginsenoside F11, a Novel Partial PPARγ Agonist, Promotes Adiponectin Oligomerization and Secretion in 3T3-L1 Adipocytes. PPAR Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-491590
Modern Language Association (MLA)
Wu, Guoyu…[et al.]. Pseudoginsenoside F11, a Novel Partial PPARγ Agonist, Promotes Adiponectin Oligomerization and Secretion in 3T3-L1 Adipocytes. PPAR Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-491590
American Medical Association (AMA)
Wu, Guoyu& Yi, Junyang& Liu, Ling& Wang, Pengcheng& Zhang, Zhijie& Li, Zhen. Pseudoginsenoside F11, a Novel Partial PPARγ Agonist, Promotes Adiponectin Oligomerization and Secretion in 3T3-L1 Adipocytes. PPAR Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-491590
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491590