Pseudoginsenoside F11, a Novel Partial PPARγ Agonist, Promotes Adiponectin Oligomerization and Secretion in 3T3-L1 Adipocytes

Abstract EN

PPARγ is a nuclear hormone receptor that functions as a master regulator of adipocyte differentiation and development.

Full PPARγ agonists, such as the thiazolidinediones (TZDs), have been widely used to treat type 2 diabetes.

However, they are characterized by undesirable side effects due to their strong agonist activities.

Pseudoginsenoside F11 (p-F11) is an ocotillol-type ginsenoside isolated from Panax quinquefolium L.

(American ginseng).

In this study, we found that p-F11 activates PPARγ with modest adipogenic activity.

In addition, p-F11 promotes adiponectin oligomerization and secretion in 3T3-L1 adipocytes.

We also found that p-F11 inhibits obesity-linked phosphorylation of PPARγ at Ser-273 by Cdk5.

Therefore, p-F11 is a novel partial PPARγ agonist, which might have the potential to be developed as a new PPARγ-targeted therapeutics for type 2 diabetes.