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A Comprehensive Review of Immunosuppression Used for Liver Transplantation
Joint Authors
Mukherjee, Sandeep
Mukherjee, Urmila
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-07-16
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Since liver transplantation was approved for the treatment of end stage liver disease, calcineurin inhibitors (CNI's) have played a critical role in the preservation of allograft function.
Unfortunately, these medications cause a variety of Side effects such as diabetes, hypertension and nephrotoxicity which in turn result in significant morbidity and reduced quality of life.
A variety of newer immunosuppressants have been evaluated over the last decade in an attempt to either substitute for CNI's or use with reduced dose CNI's while still preserving allograft function However, current data does not recommend complete cessation of CNI's due to unacceptably high rates of allograft rejection.
As these medications have their own unique adverse effects, a careful assessment on their risks and benefits is essential, particularly when additive or synergistic effects with CNI's may occur.
Furthermore, the impact of these newer medications on the risk of hepatitis C recurrence and progression remains to be elucidated.
Controlled trials are urgently required to assist transplant physicians with choosing the optimum immunosuppressive regimen for their patients.
This review will discuss commonly used immunosuppressants prescribed in liver transplantation, emerging therapties and where appropriate, the impact of these medications on the recurrence of hepatitis C after liver transplantation.
American Psychological Association (APA)
Mukherjee, Sandeep& Mukherjee, Urmila. 2009. A Comprehensive Review of Immunosuppression Used for Liver Transplantation. Journal of Transplantation،Vol. 2009, no. 2009, pp.1-20.
https://search.emarefa.net/detail/BIM-491625
Modern Language Association (MLA)
Mukherjee, Sandeep& Mukherjee, Urmila. A Comprehensive Review of Immunosuppression Used for Liver Transplantation. Journal of Transplantation No. 2009 (2009), pp.1-20.
https://search.emarefa.net/detail/BIM-491625
American Medical Association (AMA)
Mukherjee, Sandeep& Mukherjee, Urmila. A Comprehensive Review of Immunosuppression Used for Liver Transplantation. Journal of Transplantation. 2009. Vol. 2009, no. 2009, pp.1-20.
https://search.emarefa.net/detail/BIM-491625
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491625