Intrahepatic Sarcomatoid Cholangiocarcinoma

Abstract EN

Intrahepatic sarcomatoid cholangiocarcinoma is a rare but an aggressive variant of cholangiocarcinoma with a very poor prognosis.

We report the first caucasian patient who presented with a rapidly enlarging liver mass requiring hepatic resection.

Detailed histopathological analyses including immunohistochemistry and electron microscopy confirmed sarcomatoid cholangiocarcinoma.

The patient had early onset disease recurrence within 5 weeks of surgery.

Here we demonstrate that combination chemotherapy with gemcitabine and cisplatin is a potential treatment option in patients with advanced sarcomatous cholangiocarcinoma.

The patient achieved sustained partial remission with combination chemotherapy and remains alive and well more than 29 months since initial surgery.