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The Effect of Mitochondrial Dysfunction on Cytosolic Nucleotide Metabolism
Joint Authors
Lykke, Anne
Desler, Claus
Rasmussen, Lene Juel
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Several enzymes of the metabolic pathways responsible for metabolism of cytosolic ribonucleotides and deoxyribonucleotides are located in mitochondria.
Studies described in this paper suggest dysfunction of the mitochondria to affect these metabolic pathways and limit the available levels of cytosolic ribonucleotides and deoxyribonucleotides, which in turn can result in aberrant RNA and DNA synthesis.
Mitochondrial dysfunction has been linked to genomic instability, and it is possible that the limiting effect of mitochondrial dysfunction on the levels of nucleotides and resulting aberrant RNA and DNA synthesis in part can be responsible for this link.
This paper summarizes the parts of the metabolic pathways responsible for nucleotide metabolism that can be affected by mitochondrial dysfunction.
American Psychological Association (APA)
Desler, Claus& Lykke, Anne& Rasmussen, Lene Juel. 2010. The Effect of Mitochondrial Dysfunction on Cytosolic Nucleotide Metabolism. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-491630
Modern Language Association (MLA)
Desler, Claus…[et al.]. The Effect of Mitochondrial Dysfunction on Cytosolic Nucleotide Metabolism. Journal of Nucleic Acids No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-491630
American Medical Association (AMA)
Desler, Claus& Lykke, Anne& Rasmussen, Lene Juel. The Effect of Mitochondrial Dysfunction on Cytosolic Nucleotide Metabolism. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-491630
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491630