Immune Suppression in Head and Neck Cancers : A Review
Joint Authors
Hubert, Pascale
Delvenne, Philippe
Saussez, Sven
Duray, Anaëlle
Demoulin, Stéphanie
Source
Clinical and Developmental Immunology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancer in the world.
Despite significant advances in the treatment modalities involving surgery, radiotherapy, and concomitant chemoradiotherapy, the 5-year survival rate remained below 50% for the past 30 years.
The worse prognosis of these cancers must certainly be link to the fact that HNSCCs strongly influence the host immune system.
We present a critical review of our understanding of the HNSCC escape to the antitumor immune response such as a downregulation of HLA class I and/or components of APM.
Antitumor responses of HNSCC patients are compromised in the presence of functional defects or apoptosis of T-cells, both circulating and tumor-infiltrating.
Langerhans cells are increased in the first steps of the carcinogenesis but decreased in invasive carcinomas.
The accumulation of macrophages in the peritumoral areas seems to play a protumoral role by secreting VEGF and stimulating the neoangiogenesis.
American Psychological Association (APA)
Duray, Anaëlle& Demoulin, Stéphanie& Hubert, Pascale& Delvenne, Philippe& Saussez, Sven. 2011. Immune Suppression in Head and Neck Cancers : A Review. Clinical and Developmental Immunology،Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-491645
Modern Language Association (MLA)
Duray, Anaëlle…[et al.]. Immune Suppression in Head and Neck Cancers : A Review. Clinical and Developmental Immunology No. 2010 (2010), pp.1-15.
https://search.emarefa.net/detail/BIM-491645
American Medical Association (AMA)
Duray, Anaëlle& Demoulin, Stéphanie& Hubert, Pascale& Delvenne, Philippe& Saussez, Sven. Immune Suppression in Head and Neck Cancers : A Review. Clinical and Developmental Immunology. 2011. Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-491645
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491645