The Mouse Median Nerve Experimental Model in Regenerative Research
Joint Authors
Buskbjerg Jager, Sara
Geuna, Stefano
Bjerggaard Vaegter, Christian
Ronchi, Giulia
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Sciatic nerve crush injury in rat animal model is one of the most common experimental models used in regenerative research.
However, the availability of transgenic mouse for nerve regeneration studies is constantly increasing and, therefore, the shift from rat model to mouse model is, in some cases, necessary.
Moreover, since most of the human nerve lesions occur in the upper limb, it is also advantageous to shift from sciatic nerve to median nerve.
In this study we described an experimental model which involves lesions of the median nerve in the mouse.
Data showed that the finger flexor muscle contraction strength, assessed to evaluate the motor function recovery, and reached values not different from the control already 20 days after injury.
The degree of nerve regeneration evaluated with stereological methods in light microscopy showed that, 25 days after injury, the number of regenerated myelinated fibers was comparable to the control, but they were smaller with a thinner myelin thickness.
Stereological analysis made in electron microscopy confirmed these results, although the total number of fibers quantified was significantly higher compared to light microscopy analysis, due to the very small size of some fibers that can be detected only in electron microscopy.
American Psychological Association (APA)
Buskbjerg Jager, Sara& Ronchi, Giulia& Bjerggaard Vaegter, Christian& Geuna, Stefano. 2014. The Mouse Median Nerve Experimental Model in Regenerative Research. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-491649
Modern Language Association (MLA)
Buskbjerg Jager, Sara…[et al.]. The Mouse Median Nerve Experimental Model in Regenerative Research. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-491649
American Medical Association (AMA)
Buskbjerg Jager, Sara& Ronchi, Giulia& Bjerggaard Vaegter, Christian& Geuna, Stefano. The Mouse Median Nerve Experimental Model in Regenerative Research. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-491649
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491649