Murine Models of B-Cell Lymphomas : Promising Tools for Designing Cancer Therapies
Joint Authors
Sautès-Fridman, Catherine
Fabry, Zsuzsanna
Touitou, Valérie
Galand, Claire
Donnou, Sabrina
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Human B-cell lymphomas, the fourth most common hematologic malignancy, are currently the subject of extensive research.
The limited accessibility of biopsies, the heterogeneity among patients, and the subtypes of lymphomas have necessitated the development of animal models to decipher immune escape mechanisms and design new therapies.
Here, we summarize the cell lines and murine models used to study lymphomagenesis, the lymphoma microenvironment, and the efficacy of new therapies.
These data allow us to understand the role of the immune system in the fight against tumors.
Exploring the advantages and limitations of immunocompetent versus immunodeficient models improves our understanding of the molecular and cellular mechanisms of tumor genesis and development as well as the fundamental processes governing the interaction of tumors and their host tissues.
We posit that these basic preclinical investigations will open up new and promising approaches to designing better therapies.
American Psychological Association (APA)
Donnou, Sabrina& Galand, Claire& Touitou, Valérie& Sautès-Fridman, Catherine& Fabry, Zsuzsanna. 2012. Murine Models of B-Cell Lymphomas : Promising Tools for Designing Cancer Therapies. Advances in Hematology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-491651
Modern Language Association (MLA)
Donnou, Sabrina…[et al.]. Murine Models of B-Cell Lymphomas : Promising Tools for Designing Cancer Therapies. Advances in Hematology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-491651
American Medical Association (AMA)
Donnou, Sabrina& Galand, Claire& Touitou, Valérie& Sautès-Fridman, Catherine& Fabry, Zsuzsanna. Murine Models of B-Cell Lymphomas : Promising Tools for Designing Cancer Therapies. Advances in Hematology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-491651
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491651