Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways : A Meta-Analysis
Joint Authors
Nakanishi, Yoichi
Takayama, Koichi
Kiyohara, Chikako
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-14
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and are suggested to be related to lung cancer risk.
We conducted a meta-analysis of epidemiologic studies on the association between genetic polymorphisms in both base excision repair and nucleotide excision repair pathways, and lung cancer.
We found xeroderma pigmentosum complementation group A (XPA) G23A (odds ratio (OR) =0.76, 95% confidence interval (CI) =0.61–0.94), 8-oxoguanine DNA glycosylase 1 (OGG1) Ser326Cys (OR=1.22, 95% CI=1.02–1.45), and excision repair cross-complementing group 2 (ERCC2) Lys751Gln (OR=1.27, 95% CI=1.10–1.46) polymorphisms were associated with lung cancer risk.
Considering the data available, it can be conjectured that if there is any risk association between a single SNP and lung cancer, the risk fluctuation will probably be minimal.
Advances in the identification of new polymorphisms and in high-throughput genotyping techniques will facilitate the analysis of multiple genes in multiple DNA repair pathways.
Therefore, it is likely that the defining feature of future epidemiologic studies will be the simultaneous analysis of large samples of cases and controls.
American Psychological Association (APA)
Kiyohara, Chikako& Takayama, Koichi& Nakanishi, Yoichi. 2010. Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways : A Meta-Analysis. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-491661
Modern Language Association (MLA)
Kiyohara, Chikako…[et al.]. Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways : A Meta-Analysis. Journal of Nucleic Acids No. 2010 (2010), pp.1-17.
https://search.emarefa.net/detail/BIM-491661
American Medical Association (AMA)
Kiyohara, Chikako& Takayama, Koichi& Nakanishi, Yoichi. Lung Cancer Risk and Genetic Polymorphisms in DNA Repair Pathways : A Meta-Analysis. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-491661
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491661