Mitochondrial Cytochrome c Oxidase Subunit 1 Sequence Variation in Prostate Cancer

Joint Authors

Petros, John A.
Arnold, Rebecca S.
Scott, Takara A.

Source

Scientifica

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-07-10

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Natural & Life Sciences (Multidisciplinary)
Diseases

Abstract EN

Purpose.

Mitochondrial DNA (mtDNA) mutations have been described in every adult neoplasm including prostate cancer.

There are marked racial differences in mutations within the cytochrome c oxidase subunit 1 (COI) gene in individuals with prostate cancer (PCa).

The purpose of this study was to identify the variation in COI gene sequence in African and Caucasian Americans with prostate cancer.

Methods.

We sequenced the COI gene from peripheral blood in 482 prostate cancer patients and 189 controls.

All bases that differed from the revised Cambridge Reference Sequence (rCRS) were classified as either silent or missense and the compiled alterations were then compared between races and published reports.

Results and Conclusions.

We found inherited mtDNA COI missense variants in 8.8% of Caucasian prostate cancer patients (vs.

0.0% controls) and 72.8% of African-American prostate cancer patients (vs.

64.3% controls) A total of 144 COI variants were identified, of which 30 were missense mutations.

Of 482 PCa patients, 116 (24.1%) had one or more missense mutations.

Further evaluation of this gene and these mutations may allow for the identification of genetically at-risk populations.

The high rate of COI mutations in African-Americans may account for some of the racial disparity observed in prostate cancer.

American Psychological Association (APA)

Scott, Takara A.& Arnold, Rebecca S.& Petros, John A.. 2012. Mitochondrial Cytochrome c Oxidase Subunit 1 Sequence Variation in Prostate Cancer. Scientifica،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-491664

Modern Language Association (MLA)

Scott, Takara A.…[et al.]. Mitochondrial Cytochrome c Oxidase Subunit 1 Sequence Variation in Prostate Cancer. Scientifica No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-491664

American Medical Association (AMA)

Scott, Takara A.& Arnold, Rebecca S.& Petros, John A.. Mitochondrial Cytochrome c Oxidase Subunit 1 Sequence Variation in Prostate Cancer. Scientifica. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-491664

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-491664