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Adiponectin, Leptin, and Chemerin in Elderly Patients with Type 2 Diabetes Mellitus : A Close Linkage with Obesity and Length of the Disease
Joint Authors
Coimbra, Susana
Santos-Silva, Alice
Neuparth, Maria João
Brandão Proença, Jorge
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Obesity, insulin resistance, and aging are closely associated and adipokines seem to have a crucial role in their pathophysiology.
We aim to study the relationship between aging and chemerin, adiponectin, and leptin levels in type 2 diabetes mellitus (T2DM).
Age correlated positively with chemerin and leptin and inversely with adiponectin.
Body mass index (BMI) correlated positively with leptin (in males) and chemerin and inversely with adiponectin.
The patients with ≥65 years (n=34) showed significantly higher leptin and chemerin and lower adiponectin levels than middle-aged (38–64 years) patients (n=39) and controls (n=20).
After statistical adjustment for length of disease, there was a loss of significance, between T2DM groups, for adiponectin and, in female, for leptin.
In the older group, BMI correlated with adiponectin and with leptin, but not with chemerin.
Adiponectin and leptin levels in elderly T2DM patients seem to be closely linked to obesity and to length of the disease.
In elderly T2DM patients, chemerin concentrations are increased and seem to be independent of length of disease and BMI, suggesting that adipocyte dysfunction is enhanced with aging.
The understanding of the glucose homeostasis impairment in the elderly is mandatory in order to achieve ways to improve their quality of life and longevity.
American Psychological Association (APA)
Coimbra, Susana& Brandão Proença, Jorge& Santos-Silva, Alice& Neuparth, Maria João. 2014. Adiponectin, Leptin, and Chemerin in Elderly Patients with Type 2 Diabetes Mellitus : A Close Linkage with Obesity and Length of the Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-491680
Modern Language Association (MLA)
Coimbra, Susana…[et al.]. Adiponectin, Leptin, and Chemerin in Elderly Patients with Type 2 Diabetes Mellitus : A Close Linkage with Obesity and Length of the Disease. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-491680
American Medical Association (AMA)
Coimbra, Susana& Brandão Proença, Jorge& Santos-Silva, Alice& Neuparth, Maria João. Adiponectin, Leptin, and Chemerin in Elderly Patients with Type 2 Diabetes Mellitus : A Close Linkage with Obesity and Length of the Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-491680
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491680