Synthesis, Novel Crystal Structure, and β-Amyloid Binding Property of Re(I) (tricarbonyl)+ EHIDA Analogue
Joint Authors
Zhu, Lin
Zhang, Huabei
Yang, Yang
Zhang, Jia Xin
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A neutral compound Re(CO)3(L) (L: 2-((2-(2,6-diethylphenylamino)-2-oxoethyl)(2-ethoxy-2-oxoethyl)amino)acetic acid, an IDA analogue) has been synthesized and evaluated for in vitro imaging probes of β-amyloid (Aβ) aggregates.
Results of X-ray measurement of Re(CO)3(L) demonstrated that the coordination mode of Re(CO)3(L) was different from that of classical Re/Tc(I) (tricarbonyl)-IDA analogues; the structure of Re(CO)3(L) was confirmed by means of infrared spectrum, HPLC-UV, TOF MS, and X-ray measurements (Cambridge Crystallographic Data Centre number is 732731): monoclinic P21/c, a=15.6636 (12) Å, b=10.9360 (8) Å, c=27.756 (2) Å, α=90.000 (0)∘, β=90.783 (5)∘, γ=90.000 (0)∘, and Z=8.
The binding affinity for β-amyloid plaques was assessed by in vitro binding assay using preformed synthetic Aβ(1–40) aggregates.
The neutral compound Re(CO)3(L) showed binding affinity to Aβ aggregates at micromolar level by fluorescence spectroscopy, and this work will encourage for further exploration of imaging agents labeled by T99mc(CO)3+ center as probes for β-amyloid plaques in vivo.
American Psychological Association (APA)
Yang, Yang& Zhang, Jia Xin& Zhu, Lin& Zhang, Huabei. 2009. Synthesis, Novel Crystal Structure, and β-Amyloid Binding Property of Re(I) (tricarbonyl)+ EHIDA Analogue. Bioinorganic Chemistry and Applications،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-491750
Modern Language Association (MLA)
Yang, Yang…[et al.]. Synthesis, Novel Crystal Structure, and β-Amyloid Binding Property of Re(I) (tricarbonyl)+ EHIDA Analogue. Bioinorganic Chemistry and Applications No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-491750
American Medical Association (AMA)
Yang, Yang& Zhang, Jia Xin& Zhu, Lin& Zhang, Huabei. Synthesis, Novel Crystal Structure, and β-Amyloid Binding Property of Re(I) (tricarbonyl)+ EHIDA Analogue. Bioinorganic Chemistry and Applications. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-491750
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491750