Differential Impact of Adherence to Pegylated Interferon and Ribavirin in the Treatment of Genotype 1 High Viral Titer Chronic Hepatitis C
Joint Authors
Numata, Makoto
Ohno, Takashi
Hirose, Shunji
Nishizaki, Yasuhiro
Takashimizu, Shinji
Mine, Tetsuya
Yamada, Takuji
Kagawa, Tatehiro
Nakano, Atsushi
Watanabe, Norihito
Atsukawa, Kazuhiro
Kamochi, Jun-ichiro
Shiraishi, Koichi
Watanabe, Tetsu
Kojima, Sei-ichiro
Motegi, Shigeyuki
Nagata, Naruhiko
Tei, Yoshihiro
Wasada, Mitsuru
Shiozawa, Hirokazu
Source
Hepatitis Research and Treatment
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
To clarify the impact of adherence, we treated 122 genotype 1 high viral titer chronic hepatitis C patients with pegylated interferon (peg-IFN) and ribavirin for 48 weeks at nine referral hospitals, and evaluated the prognostic factors with a focus on the adherence to the treatment.
This study included 68 (55.7%) treatment-naïve patients and 54 (44.3%) patients who did not respond to the previous treatment.
Multivariate analysis revealed adherence to peg-IFN and ribavirin as the only significant predictor.
Sustained virological response (SVR) rate was 72.2%, 19.0%, and 27.3% in patients given ≥80%, 60%–80%, and <60% dose peg-IFN, respectively, and was 68.6%, 41.2%, and 5.3% in those given ≥80%, 60%–80%, and <60% dose ribavirin, respectively.
SVR rate sharply fell when exposure to peg-IFN was below 80% whereas it decreased in a stepwise manner as for ribavirin.
Therefore, ≥80% of peg-IFN and as much as possible dose of ribavirin are desired to achieve SVR in the treatment of genotype 1 high viral titer chronic hepatitis C.
American Psychological Association (APA)
Numata, Makoto& Kagawa, Tatehiro& Kojima, Sei-ichiro& Hirose, Shunji& Nagata, Naruhiko& Shiraishi, Koichi…[et al.]. 2010. Differential Impact of Adherence to Pegylated Interferon and Ribavirin in the Treatment of Genotype 1 High Viral Titer Chronic Hepatitis C. Hepatitis Research and Treatment،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-491753
Modern Language Association (MLA)
Numata, Makoto…[et al.]. Differential Impact of Adherence to Pegylated Interferon and Ribavirin in the Treatment of Genotype 1 High Viral Titer Chronic Hepatitis C. Hepatitis Research and Treatment No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-491753
American Medical Association (AMA)
Numata, Makoto& Kagawa, Tatehiro& Kojima, Sei-ichiro& Hirose, Shunji& Nagata, Naruhiko& Shiraishi, Koichi…[et al.]. Differential Impact of Adherence to Pegylated Interferon and Ribavirin in the Treatment of Genotype 1 High Viral Titer Chronic Hepatitis C. Hepatitis Research and Treatment. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-491753
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491753