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Homocysteine as a Risk Factor for Atherosclerosis : Is Its Conversion to S-Adenosyl-L-Homocysteine the Key to Deregulated Lipid Metabolism?
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Homocysteine (Hcy) has been recognized for the past five decades as a risk factor for atherosclerosis.
However, the role of Hcy in the pathological changes associated with atherosclerosis as well as the pathological mechanisms triggered by Hcy accumulation is poorly understood.
Due to the reversal of the physiological direction of the reaction catalyzed by S-adenosyl-L-homocysteine hydrolase Hcy accumulation leads to the synthesis of S-adenosyl-L-homocysteine (AdoHcy).
AdoHcy is a strong product inhibitor of S-adenosyl-L-methionine (AdoMet)-dependent methyltransferases, and to date more than 50 AdoMet-dependent methyltransferases that methylate a broad spectrum of cellular compounds including nucleic acids, proteins and lipids have been identified.
Phospholipid methylation is the major consumer of AdoMet, both in mammals and in yeast.
AdoHcy accumulation induced either by Hcy supplementation or due to S-adenosyl-L-homocysteine hydrolase deficiency results in inhibition of phospholipid methylation in yeast.
Moreover, yeast cells accumulating AdoHcy also massively accumulate triacylglycerols (TAG).
Similarly, Hcy supplementation was shown to lead to increased TAG and sterol synthesis as well as to the induction of the unfolded protein response (UPR) in mammalian cells.
In this review a model of deregulation of lipid metabolism in response to accumulation of AdoHcy in Hcy-associated pathology is proposed.
American Psychological Association (APA)
Tehlivets, Oksana. 2011. Homocysteine as a Risk Factor for Atherosclerosis : Is Its Conversion to S-Adenosyl-L-Homocysteine the Key to Deregulated Lipid Metabolism?. Journal of Lipids،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-491766
Modern Language Association (MLA)
Tehlivets, Oksana. Homocysteine as a Risk Factor for Atherosclerosis : Is Its Conversion to S-Adenosyl-L-Homocysteine the Key to Deregulated Lipid Metabolism?. Journal of Lipids No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-491766
American Medical Association (AMA)
Tehlivets, Oksana. Homocysteine as a Risk Factor for Atherosclerosis : Is Its Conversion to S-Adenosyl-L-Homocysteine the Key to Deregulated Lipid Metabolism?. Journal of Lipids. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-491766
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491766