Caffeic Acid Phenethyl Ester Protects against Amphotericin B Induced Nephrotoxicity in Rat Model
Joint Authors
Sezer, Mehmet Tuğrul
Aksu, Oğuzhan
Bayram, Dilek Şenol
Yılmaz, H. Ramazan
Demir, Murat
Altuntaş, Ayşegül
Uz, Efkan
Altuntaş, Atila
Gökçimen, Alparslan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present study was conducted to investigate whether caffeic acid phenethyl ester (CAPE), an active component of propolis extract, has a protective effect on amphotericin B induced nephrotoxicity in rat models.
Male Wistar-Albino rats were randomly divided into four groups: (I) control group (n = 10), (II) CAPE group (n = 9) which received 10 μmol/kg CAPE intraperitoneally (i.p.), (III) amphotericin B group (n = 7) which received one dose of 50 mg/kg amphotericin B, and (IV) amphotericin B plus CAPE group (n = 7) which received 10 μmol/kg CAPE i.p.
and one dose of 50 mg/kg amphotericin B.
The left kidney was evaluated histopathologically for nephrotoxicity.
Levels of malondialdehyde (MDA), nitric oxide (NO), enzyme activities including catalase (CAT), and superoxide dismutase (SOD) were measured in the right kidney.
Histopathological damage was prominent in the amphotericin B group compared to controls, and the severity of damage was lowered by CAPE administration.
The activity of SOD, MDA, and NO levels increased and catalase activity decreased in the amphotericin B group compared to the control group (P=0.0001, P=0.003, P=0.0001, and P=0.0001, resp.).
Amphotericin B plus CAPE treatment caused a significant decrease in MDA, NO levels, and SOD activity (P=0.04, P=0.02, and P=0.0001, resp.) and caused an increase in CAT activity compared with amphotericin B treatment alone (P=0.005).
CAPE treatment seems to be an effective adjuvant agent for the prevention of amphotericin B nephrotoxicity in rat models.
American Psychological Association (APA)
Altuntaş, Atila& Yılmaz, H. Ramazan& Altuntaş, Ayşegül& Uz, Efkan& Demir, Murat& Gökçimen, Alparslan…[et al.]. 2014. Caffeic Acid Phenethyl Ester Protects against Amphotericin B Induced Nephrotoxicity in Rat Model. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-491781
Modern Language Association (MLA)
Altuntaş, Atila…[et al.]. Caffeic Acid Phenethyl Ester Protects against Amphotericin B Induced Nephrotoxicity in Rat Model. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-491781
American Medical Association (AMA)
Altuntaş, Atila& Yılmaz, H. Ramazan& Altuntaş, Ayşegül& Uz, Efkan& Demir, Murat& Gökçimen, Alparslan…[et al.]. Caffeic Acid Phenethyl Ester Protects against Amphotericin B Induced Nephrotoxicity in Rat Model. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-491781
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491781