Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C
Joint Authors
Hamdy, Nadia M.
Rizk, Hanan H.
El-Mesallamy, Hala O.
El-Zayadi, Abdel-Rahman
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Highlighting the apelin system would present a new therapeutic target for liver disease.
Apelin; endogenous ligand for the orphan receptor APJ, was recently suggested to be associated with fibrosis progression and cirrhosis in addition to insulin resistance (IR) and inflammation.
The present study was conducted to evaluate blood apelin level changes among 73 chronic hepatitis C (CHC) Egyptian patients and if associated with body mass index (BMI), IR, and tumor necrosis factor-alpha (TNF-α).
Serum apelin levels were significantly higher in patients with CHC with median value (3.25) when compared with controls (1.11), at P<0.0001, with significant apelin variations among asymptomatic carriers (ASC), fibrosis, and cirrhosis patients, and also among obese and nonobese patients.
Multiple regression analysis depicted that BMI, triglycerides, and total cholesterol were independent correlation factors to apelin levels, whereas TNF-α was found to be significantly negatively correlated to adjusted apelin in CHC patients (r=−0.5944, P<0.0001).
IR was positively correlated to adjusted apelin in CHC patients (r=0.2663, P<0.05).
Conclusion.
Apelin level varies among stages of CHC, which may contribute to fibrosis progression.
In addition, obesity and IR could act as comorbid factors affecting apelin level in patients with CHC.
American Psychological Association (APA)
El-Mesallamy, Hala O.& Hamdy, Nadia M.& Rizk, Hanan H.& El-Zayadi, Abdel-Rahman. 2011. Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-491787
Modern Language Association (MLA)
El-Mesallamy, Hala O.…[et al.]. Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C. Mediators of Inflammation No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-491787
American Medical Association (AMA)
El-Mesallamy, Hala O.& Hamdy, Nadia M.& Rizk, Hanan H.& El-Zayadi, Abdel-Rahman. Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-491787
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491787