Natural History of the Bruise : Formation, Elimination, and Biological Effects of Oxidized Hemoglobin
Joint Authors
Balla, József
Balla, György
Jeney, Viktória
Eaton, John W.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Numerous disease states are associated with hemolysis or hemorrhage.
Because red cells in the extravascular space tend to lyse quickly, hemoglobin (Hb) is released and is prone to autoxidation producing MetHb.
Inorganic and organic peroxides may convert Hb and MetHb to higher oxidation states such as ferrylHb.
FerrylHb is not a single chemical entity but is a mixture of globin- and porphyrin-centered radicals and covalently cross-linked Hb multimers.
Oxidized Hb species are potent prooxidants caused mainly by heme release from oxidized Hb.
Moreover, ferrylHb is a strong proinflammatory agonist that targets vascular endothelial cells.
This proinflammatory effect of ferrylHb requires actin polymerization, is characterized by the upregulation of proinflammatory adhesion molecules, and is independent of heme release.
Deleterious effects of native Hb are controlled by haptoglobin (Hp) that binds cell-free Hb avidly and facilitates its removal from circulation through the CD163 macrophage scavenger receptor-mediated endocytosis.
Under circumstances of Hb oxidation, Hp can prevent heme release from MetHb, but unfortunately the Hp-mediated removal of Hb is severely compromised when Hb is structurally altered such as in ferrylHb allowing deleterious downstream reactions to occur even in the presence of Hp.
American Psychological Association (APA)
Jeney, Viktória& Eaton, John W.& Balla, György& Balla, József. 2013. Natural History of the Bruise : Formation, Elimination, and Biological Effects of Oxidized Hemoglobin. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-491829
Modern Language Association (MLA)
Jeney, Viktória…[et al.]. Natural History of the Bruise : Formation, Elimination, and Biological Effects of Oxidized Hemoglobin. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-491829
American Medical Association (AMA)
Jeney, Viktória& Eaton, John W.& Balla, György& Balla, József. Natural History of the Bruise : Formation, Elimination, and Biological Effects of Oxidized Hemoglobin. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-491829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491829