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Resveratrol Regulates Antioxidant Status, Inhibits Cytokine Expression and Restricts Apoptosis in Carbon Tetrachloride Induced Rat Hepatic Injury
Joint Authors
Sannigrahi, Santanu
Majumdar, Subhabrota
Ghosh, Balaram
Sarkar, Biswajit
Roy, Souvik
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Recent studies indicate the chemopreventive role of resveratrol in many animal models like ischemia, rheumatoid arthritis, human cancer, and diabetes.
The present study was designed to investigate the chemopreventive potential of resveratrol in rat hepatic injury model by carbon tetrachloride.
Male Wistar rats were treated with carbon tetrachloride (0.4 g/kg body weight) intraperitoneally daily for 8 weeks.
Resveratrol (100 mg/kg, 200 mg/kg body weight) was given orally from first day until the last day of experiment.
The investigation assesses the effect of resveratrol on morphological, oxidative status, histopathological, immunohistochemical, and apoptotic analysis in carbon tetrachloride-challenged liver tissue.
The study indicated that the inflammatory cytokines TNF-α and IL-6 were profoundly expressed in experimental rats, whereas resveratrol decreases the immunopositivity of TNF-α and IL-6 and restored the altered architectural structure of challenged hepatic tissue.
Resveratrol also protects liver cells by suppressing oxidative stress and apoptosis.
American Psychological Association (APA)
Roy, Souvik& Sannigrahi, Santanu& Majumdar, Subhabrota& Ghosh, Balaram& Sarkar, Biswajit. 2011. Resveratrol Regulates Antioxidant Status, Inhibits Cytokine Expression and Restricts Apoptosis in Carbon Tetrachloride Induced Rat Hepatic Injury. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-491839
Modern Language Association (MLA)
Roy, Souvik…[et al.]. Resveratrol Regulates Antioxidant Status, Inhibits Cytokine Expression and Restricts Apoptosis in Carbon Tetrachloride Induced Rat Hepatic Injury. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-491839
American Medical Association (AMA)
Roy, Souvik& Sannigrahi, Santanu& Majumdar, Subhabrota& Ghosh, Balaram& Sarkar, Biswajit. Resveratrol Regulates Antioxidant Status, Inhibits Cytokine Expression and Restricts Apoptosis in Carbon Tetrachloride Induced Rat Hepatic Injury. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-491839
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491839