Regulation of ENaC-Mediated Sodium Reabsorption by Peroxisome Proliferator-Activated Receptors
Joint Authors
Pavlov, Tengis S.
Imig, John D.
Staruschenko, Alexander
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptors (PPARs) are members of a steroid hormone receptor superfamily that responds to changes in lipid and glucose homeostasis.
Peroxisomal proliferator-activated receptor subtype γ (PPARγ) has received much attention as the target for antidiabetic drugs, as well as its role in responding to endogenous compounds such as prostaglandin J2.
However, thiazolidinediones (TZDs), the synthetic agonists of the PPARγ are tightly associated with fluid retention and edema, as potentially serious side effects.
The epithelial sodium channel (ENaC) represents the rate limiting step for sodium absorption in the renal collecting duct.
Consequently, ENaC is a central effector impacting systemic blood volume and pressure.
The role of PPARγ agonists on ENaC activity remains controversial.
While PPARγ agonists were shown to stimulate ENaC-mediated renal salt absorption, probably via Serum- and Glucocorticoid-Regulated Kinase 1 (SGK1), other studies reported that PPARγ agonist-induced fluid retention is independent of ENaC activity.
The current paper provides new insights into the control and function of ENaC and ENaC-mediated sodium transport as well as several other epithelial channels/transporters by PPARs and particularly PPARγ.
The potential contribution of arachidonic acid (AA) metabolites in PPAR-dependent mechanisms is also discussed.
American Psychological Association (APA)
Pavlov, Tengis S.& Imig, John D.& Staruschenko, Alexander. 2010. Regulation of ENaC-Mediated Sodium Reabsorption by Peroxisome Proliferator-Activated Receptors. PPAR Research،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-491847
Modern Language Association (MLA)
Pavlov, Tengis S.…[et al.]. Regulation of ENaC-Mediated Sodium Reabsorption by Peroxisome Proliferator-Activated Receptors. PPAR Research No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-491847
American Medical Association (AMA)
Pavlov, Tengis S.& Imig, John D.& Staruschenko, Alexander. Regulation of ENaC-Mediated Sodium Reabsorption by Peroxisome Proliferator-Activated Receptors. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-491847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491847