Cajachalcone : An Antimalarial Compound from Cajanus cajan Leaf Extract
Joint Authors
Ogbole, O. O.
Wright, Colin W.
Ajaiyeoba, E. O.
Houghton, P. J.
Abiodun, O. O.
Ashidi, J. S.
Source
Journal of Parasitology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Cajanus cajan L, a member of the family Fabaceae, was identified from the Nigerian antimalarial ethnobotany as possessing antimalarial properties.
The bioassay-guided fractionation of the crude methanol extract of C.
cajan leaves was done in vitro using the multiresistant strain of Plasmodium falciparum (K1) in the parasite lactate dehydrogenase assay.
Isolation of compound was achieved by a combination of chromatographic techniques, while the structure of the compound was elucidated by spectroscopy.
This led to the identification of a cajachalcone, 2′,6′-dihydroxy-4-methoxy chalcone, as the biologically active constituent from the ethyl acetate fraction.
Cajachalcone had an IC50 value of 2.0 μg/mL (7.4 μM) and could be a lead for anti-malarial drug discovery.
American Psychological Association (APA)
Ajaiyeoba, E. O.& Ogbole, O. O.& Abiodun, O. O.& Ashidi, J. S.& Houghton, P. J.& Wright, Colin W.. 2013. Cajachalcone : An Antimalarial Compound from Cajanus cajan Leaf Extract. Journal of Parasitology Research،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-491851
Modern Language Association (MLA)
Ajaiyeoba, E. O.…[et al.]. Cajachalcone : An Antimalarial Compound from Cajanus cajan Leaf Extract. Journal of Parasitology Research No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-491851
American Medical Association (AMA)
Ajaiyeoba, E. O.& Ogbole, O. O.& Abiodun, O. O.& Ashidi, J. S.& Houghton, P. J.& Wright, Colin W.. Cajachalcone : An Antimalarial Compound from Cajanus cajan Leaf Extract. Journal of Parasitology Research. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-491851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491851