Advancements in the Treatment of Metastatic Breast Cancer (MBC) : The Role of Ixabepilone
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Successful management of breast cancer in the metastatic setting is often confounded by resistance to chemotherapeutics, in particular anthracyclines and taxanes.
The limited number of effective treatment options for patients with more aggressive biological subtypes, such as triple-negative metastatic breast cancer, is especially concerning.
As such, a therapy clinically proven to be effective in this subtype would be of great value.
Ixabepilone, a novel synthetic lactam analog of epothilone B, demonstrated better clinical outcomes in metastatic disease, particularly in triple-negative breast cancer.
Most recently, studies have shown the activity of ixabepilone in the neoadjuvant setting, suggesting a role for this drug in primary disease.
Notably, treating in the neoadjuvant setting might allow clinicians to explore the predictive value of biomarkers and response to treatment, as pharmacogenomic approaches to therapy continue to evolve.
In this article, we review the efficacy and safety data of ixabepilone as a monotherapy and as a component of combination therapy for metastatic and primary breast cancer.
American Psychological Association (APA)
Cristofanilli, Massimo. 2012. Advancements in the Treatment of Metastatic Breast Cancer (MBC) : The Role of Ixabepilone. Journal of Oncology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-491864
Modern Language Association (MLA)
Cristofanilli, Massimo. Advancements in the Treatment of Metastatic Breast Cancer (MBC) : The Role of Ixabepilone. Journal of Oncology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-491864
American Medical Association (AMA)
Cristofanilli, Massimo. Advancements in the Treatment of Metastatic Breast Cancer (MBC) : The Role of Ixabepilone. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-491864
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491864