The Relation between Inflammation and Neuropsychological Test Performance
Joint Authors
Hall, James R.
Hynan, Linda
Barber, Robert C.
Balldin, Valerie H.
Diaz-Arrastia, Ramon
O'Bryant, Sid E.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Considerable research documents an association between pro- and anti-inflammatory markers and Alzheimer's disease (AD), yet the differential relation between these markers and neuropsychological functioning in AD and nondemented controls has received less attention.
The current study sought to evaluate the relationship between peripheral markers of inflammation (both pro- and anti-inflammatory) and neuropsychological functioning through the Texas Alzheimer's Research and Care Consortium (TARCC) cohort.
Methods.
There were 320 participants (Probable AD n=124, Controls n=196) in the TARCC Longitudinal Research Cohort available for analysis.
Regression analyses were utilized to examine the relation between proinflammatory and anti-inflammatory markers and neuropsychological functioning.
Follow-up analyses were conducted separately by case versus control status.
Results.
Proinflammatory and anti-inflammatory markers were found to be associated with neuropsychological testing.
Third tertile proinflammatory markers were negatively associated with measures of attention and language, and anti-inflammatory markers were positively associated with measures of immediate verbal memory and delayed verbal and visual memory.
Conclusions.
These findings support the link between peripheral inflammatory markers and neuropsychological functioning and suggest the utility of examining profiles of inflammatory markers in the future.
American Psychological Association (APA)
Balldin, Valerie H.& Hall, James R.& Barber, Robert C.& Hynan, Linda& Diaz-Arrastia, Ramon& O'Bryant, Sid E.. 2012. The Relation between Inflammation and Neuropsychological Test Performance. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-491867
Modern Language Association (MLA)
Balldin, Valerie H.…[et al.]. The Relation between Inflammation and Neuropsychological Test Performance. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-491867
American Medical Association (AMA)
Balldin, Valerie H.& Hall, James R.& Barber, Robert C.& Hynan, Linda& Diaz-Arrastia, Ramon& O'Bryant, Sid E.. The Relation between Inflammation and Neuropsychological Test Performance. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-491867
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491867