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Biochemical Bone Turnover Markers and Osteoporosis in Older Men : Where Are We?
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
In men aged less than 60, the association of serum and urinary levels of biochemical bone turnover markers (BTMs) and bone mineral density (BMD) is weak or not significant.
After this age, higher BTM levels are correlated weakly, but significantly, with lower BMD and faster bone loss.
Limited data from the cohort studies suggest that BTM measurement does not improve the prediction of fragility fractures in older men in comparison with age, BMD, history of falls and fragility fractures.
Testosterone replacement therapy (TRT) decreases bone resorption.
During TRT, bone formation markers slightly increase (direct effect on osteoblasts), then decrease (slowdown of bone turnover).
Bisphosphonates (alendronate, risedronate, ibandronate, zoledronate) induce a rapid decrease in bone resorption followed by a milder decrease in bone formation.
In men receiving antiresorptive therapy for prostate cancer, zoledronate, denosumab and toremifene decrease significantly levels of bone resorption and bone formation markers.
Teriparatide induced a rapid increase in serum concentrations of bone formation markers followed by an increase in bone resorption.
We need more studies on the utility of BTM measurement for the improvement of the persistence and adherence to the anti-osteoporotic treatment in men.
American Psychological Association (APA)
Szulc, Pawel. 2011. Biochemical Bone Turnover Markers and Osteoporosis in Older Men : Where Are We?. Journal of Osteoporosis،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-491885
Modern Language Association (MLA)
Szulc, Pawel. Biochemical Bone Turnover Markers and Osteoporosis in Older Men : Where Are We?. Journal of Osteoporosis No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-491885
American Medical Association (AMA)
Szulc, Pawel. Biochemical Bone Turnover Markers and Osteoporosis in Older Men : Where Are We?. Journal of Osteoporosis. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-491885
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491885