Influences of Desmin and Keratin 19 on Passive Biomechanical Properties of Mouse Skeletal Muscle
Joint Authors
Shah, Sameer B.
O'Neill, Andrea
Love, James M.
Lovering, Richard M.
Bloch, Robert J.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In skeletal muscle fibers, forces must be transmitted between the plasma membrane and the intracellular contractile lattice, and within this lattice between adjacent myofibrils.
Based on their prevalence, biomechanical properties and localization, desmin and keratin intermediate filaments (IFs) are likely to participate in structural connectivity and force transmission.
We examined the passive load-bearing response of single fibers from the extensor digitorum longus (EDL) muscles of young (3 months) and aged (10 months) wild-type, desmin-null, K19-null, and desmin/K19 double-null mice.
Though fibers are more compliant in all mutant genotypes compared to wild-type, the structural response of each genotype is distinct, suggesting multiple mechanisms by which desmin and keratin influence the biomechanical properties of myofibers.
This work provides additional insight into the influences of IFs on structure-function relationships in skeletal muscle.
It may also have implications for understanding the progression of desminopathies and other IF-related myopathies.
American Psychological Association (APA)
Shah, Sameer B.& Love, James M.& O'Neill, Andrea& Lovering, Richard M.& Bloch, Robert J.. 2012. Influences of Desmin and Keratin 19 on Passive Biomechanical Properties of Mouse Skeletal Muscle. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-491888
Modern Language Association (MLA)
Shah, Sameer B.…[et al.]. Influences of Desmin and Keratin 19 on Passive Biomechanical Properties of Mouse Skeletal Muscle. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-491888
American Medical Association (AMA)
Shah, Sameer B.& Love, James M.& O'Neill, Andrea& Lovering, Richard M.& Bloch, Robert J.. Influences of Desmin and Keratin 19 on Passive Biomechanical Properties of Mouse Skeletal Muscle. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-491888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491888