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Lack of Association between TLR4 Genetic Polymorphisms and Diabetic Nephropathy in a Chinese Population
Joint Authors
Pan, Jiemin
Jia, Weiping
Sun, Xue
Wang, Tao
Chen, Miao
Jiang, Feng
Wang, Jie
Yan, Jing
Tang, Shanshan
Wang, Shiyun
Peng, Danfeng
Bao, Yu-Qian
Zhang, Rong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
Toll-like receptor 4 (TLR4) plays a central role in innate immunity.
Activation of innate immune response and subsequent chronic low-grade inflammation are thought to be involved in the pathogenesis of diabetic nephropathy.
In this study, we aimed to investigate whether TLR4 variants are associated with diabetic nephropathy in the Chinese population.
Methods.
Seven tagging single nucleotide polymorphisms (SNPs) of TLR4 based on HapMap Chinese data were genotyped in 1,455 Chinese type 2 diabetic patients.
Of these patients, 622 were diagnosed with diabetic nephropathy and 833 were patients with diabetes for over 5 years but without diabetic nephropathy.
Results.
None of the SNPs and haplotypes showed significant association to diabetic nephropathy in our study.
No association between the SNPs and quantitative traits was observed either.
Conclusion.
We concluded that common variants within TLR4 genes were not associated with diabetic nephropathy in the Chinese type 2 diabetes patients.
American Psychological Association (APA)
Peng, Danfeng& Wang, Jie& Pan, Jiemin& Zhang, Rong& Tang, Shanshan& Jiang, Feng…[et al.]. 2014. Lack of Association between TLR4 Genetic Polymorphisms and Diabetic Nephropathy in a Chinese Population. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-491898
Modern Language Association (MLA)
Peng, Danfeng…[et al.]. Lack of Association between TLR4 Genetic Polymorphisms and Diabetic Nephropathy in a Chinese Population. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-491898
American Medical Association (AMA)
Peng, Danfeng& Wang, Jie& Pan, Jiemin& Zhang, Rong& Tang, Shanshan& Jiang, Feng…[et al.]. Lack of Association between TLR4 Genetic Polymorphisms and Diabetic Nephropathy in a Chinese Population. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-491898
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491898