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Proteomic Definitions of Mesenchymal Stem Cells
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Mesenchymal stem cells (MSCs) are pluripotent cells isolated from the bone marrow and various other organs.
They are able to proliferate and self-renew, as well as to give rise to progeny of at least the osteogenic, chondrogenic, and adipogenic lineages.
Despite this functional definition, MSCs can also be defined by their expression of a distinct set of cell surface markers.
In the current paper, studies investigating the proteome of human MSCs are reviewed with the aim to identify common protein markers of MSCs.
The proteomic analysis of MSCs revealed a distinct set of proteins representing the basic molecular inventory, including proteins for (i) cell surface markers, (ii) the responsiveness to growth factors, (iii) the reuse of developmental signaling cascades in adult stem cells, (iv) the interaction with molecules of the extracellular matrix, (v) the expression of genes regulating transcription and translation, (vi) the control of the cell number, and (vii) the protection against cellular stress.
American Psychological Association (APA)
Maurer, Martin H.. 2011. Proteomic Definitions of Mesenchymal Stem Cells. Stem Cells International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-491911
Modern Language Association (MLA)
Maurer, Martin H.. Proteomic Definitions of Mesenchymal Stem Cells. Stem Cells International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-491911
American Medical Association (AMA)
Maurer, Martin H.. Proteomic Definitions of Mesenchymal Stem Cells. Stem Cells International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-491911
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491911