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Formulation of Indomethacin Colon Targeted Delivery Systems Using Polysaccharides as Carriers by Applying Liquisolid Technique
Joint Authors
Elsaghir, Hanna A.
al-Subayiel, Amal M.
Elkhodairy, Kadria A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-26
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The present study aimed at the formulation of matrix tablets for colon-specific drug delivery (CSDD) system of indomethacin (IDM) by applying liquisolid (LS) technique.
A CSDD system based on time-dependent polymethacrylates and enzyme degradable polysaccharides was established.
Eudragit RL 100 (E-RL 100) was employed as time-dependent polymer, whereas bacterial degradable polysaccharides were presented as LS systems loaded with the drug.
Indomethacin-loaded LS systems were prepared using different polysaccharides, namely, guar gum (GG), pectin (PEC), and chitosan (CH), as carriers separately or in mixtures of different ratios of 1 : 3, 1 : 1, and 3 : 1.
Liquisolid systems that displayed promising results concerning drug release rate in both pH 1.2 and pH 6.8 were compressed into tablets after the addition of the calculated amount of E-RL 100 and lubrication with magnesium stearate and talc in the ratio of 1 : 9.
It was found that E-RL 100 improved the flowability and compressibility of all LS formulations.
The release data revealed that all formulations succeeded to sustain drug release over a period of 24 hours.
Stability study indicated that PEC-based LS system as well as its matrix tablets was stable over the period of storage (one year) and could provide a minimum shelf life of two years.
American Psychological Association (APA)
Elkhodairy, Kadria A.& Elsaghir, Hanna A.& al-Subayiel, Amal M.. 2014. Formulation of Indomethacin Colon Targeted Delivery Systems Using Polysaccharides as Carriers by Applying Liquisolid Technique. BioMed Research International،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-491921
Modern Language Association (MLA)
Elkhodairy, Kadria A.…[et al.]. Formulation of Indomethacin Colon Targeted Delivery Systems Using Polysaccharides as Carriers by Applying Liquisolid Technique. BioMed Research International No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-491921
American Medical Association (AMA)
Elkhodairy, Kadria A.& Elsaghir, Hanna A.& al-Subayiel, Amal M.. Formulation of Indomethacin Colon Targeted Delivery Systems Using Polysaccharides as Carriers by Applying Liquisolid Technique. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-491921
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491921