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Potentiation of Antibiofilm Activity of Amphotericin B by Superoxide Dismutase Inhibition
Joint Authors
Meert, Els
Cammue, Bruno P. A.
De Brucker, Katrijn
Bink, Anna
Thevissen, Karin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
This study demonstrates a role for superoxide dismutases (Sods) in governing tolerance of Candida albicans biofilms to amphotericin B (AmB).
Coincubation of C.
albicans biofilms with AmB and the Sod inhibitors N,N′-diethyldithiocarbamate (DDC) or ammonium tetrathiomolybdate (ATM) resulted in reduced viable biofilm cells and increased intracellular reactive oxygen species levels as compared to incubation of biofilm cells with AmB, DDC, or ATM alone.
Hence, Sod inhibitors can be used to potentiate the activity of AmB against C.
albicans biofilms.
American Psychological Association (APA)
De Brucker, Katrijn& Bink, Anna& Meert, Els& Cammue, Bruno P. A.& Thevissen, Karin. 2013. Potentiation of Antibiofilm Activity of Amphotericin B by Superoxide Dismutase Inhibition. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-491937
Modern Language Association (MLA)
De Brucker, Katrijn…[et al.]. Potentiation of Antibiofilm Activity of Amphotericin B by Superoxide Dismutase Inhibition. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-491937
American Medical Association (AMA)
De Brucker, Katrijn& Bink, Anna& Meert, Els& Cammue, Bruno P. A.& Thevissen, Karin. Potentiation of Antibiofilm Activity of Amphotericin B by Superoxide Dismutase Inhibition. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-491937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491937