In Vitro Activity of 2-methoxy-1,4-naphthoquinone and Stigmasta-7,22-diene-3β-ol from Impatiens balsamina L. against Multiple Antibiotic-Resistant Helicobacter pylori
Joint Authors
Wang, Yuan-Chuen
Wu, Cheng-Hsun
Liao, Jyun-Ji
Wang, Jeh-Jeng
Li, Wan-Yu
Lin, Cheng-Kun
Wu, Deng-Chyang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Infection with Helicobacter pylori is strongly associated with gastric cancer and gastric adenocarcinoma.
WHO classified H.
pylori as a group 1 carcinogen in 1994.
Impatiens balsamina L.
has been used as indigenous medicine in Asia for the treatment of rheumatism, fractures and fingernail inflammation.
In this study, we isolated anti-H.
pylori compounds from this plant and investigated their anti- and bactericidal activity.
Compounds of 2-methoxy-1,4-naphthoquinone (MeONQ) and stigmasta-7,22-diene-3β-ol (spinasterol) were isolated from the pods and roots/stems/leaves of I.
balsamina L., respectively.
The minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) for MeONQ were in the ranges of 0.156–0.625 and 0.313–0.625 μg mL−1, respectively, and in the ranges of 20–80 μg mL−1 both of MICs and MBCs for spinasterol against antibiotic (clarithromycin, metronidazole and levofloxacin) resistant H.
pylori.
Notably, the activity of MeONQ was equivalent to that of amoxicillin (AMX).
The bactericidal H.
pylori action of MeONQ was dose-dependent.
Furthermore, the activity of MeONQ was not influenced by the environmental pH values (4–8) and demonstrated good thermal (121°C for 15 min) stability.
MeONQ abounds in the I.
balsamina L.
pod at the level of 4.39% (w/w db).
In conclusion, MeONQ exhibits strong potential to be developed as a candidate agent for the eradication of H.
pylori infection.
American Psychological Association (APA)
Wang, Yuan-Chuen& Li, Wan-Yu& Wu, Deng-Chyang& Wang, Jeh-Jeng& Wu, Cheng-Hsun& Liao, Jyun-Ji…[et al.]. 2011. In Vitro Activity of 2-methoxy-1,4-naphthoquinone and Stigmasta-7,22-diene-3β-ol from Impatiens balsamina L. against Multiple Antibiotic-Resistant Helicobacter pylori. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-491942
Modern Language Association (MLA)
Wang, Yuan-Chuen…[et al.]. In Vitro Activity of 2-methoxy-1,4-naphthoquinone and Stigmasta-7,22-diene-3β-ol from Impatiens balsamina L. against Multiple Antibiotic-Resistant Helicobacter pylori. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-491942
American Medical Association (AMA)
Wang, Yuan-Chuen& Li, Wan-Yu& Wu, Deng-Chyang& Wang, Jeh-Jeng& Wu, Cheng-Hsun& Liao, Jyun-Ji…[et al.]. In Vitro Activity of 2-methoxy-1,4-naphthoquinone and Stigmasta-7,22-diene-3β-ol from Impatiens balsamina L. against Multiple Antibiotic-Resistant Helicobacter pylori. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-491942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491942