A Case of Drug Reaction with Eosinophilia and Systemic Symptoms
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-27
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Drug reaction with eosinophilia and systemic symptoms (DRESS) is characterized by fever, skin rash, hematological abnormalities, and systemic involvement such as hepatitis.
DRESS usually presents 2–6 weeks after drug initiation.
DRESS should be suspected on clinical grounds in the setting of the introduction of new drug therapy and is most commonly described after the introduction of aromatic anticonvulsants, allopurinol, or antiretroviral therapies.
We describe here a case of DRESS due to phenytoin exposure with complete resolution on drug discontinuation.
Our patient developed DRESS with a skin rash, lymphadenopathy, and markedly abnormal liver enzymes, 4 weeks after drug initiation following drainage of a brain abscess.
He was initially diagnosed as having a recurrence of the abscess or sepsis of another origin.
It is important to recognise the possibility of DRESS in this setting, as a good outcome depends on the immediate withdrawal of the offending drug.
A mortality rate of up to 10% has been described in unrecognised cases.
American Psychological Association (APA)
Kellett, Sally& Cock, Charles. 2012. A Case of Drug Reaction with Eosinophilia and Systemic Symptoms. Case Reports in Medicine،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-491988
Modern Language Association (MLA)
Kellett, Sally& Cock, Charles. A Case of Drug Reaction with Eosinophilia and Systemic Symptoms. Case Reports in Medicine No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-491988
American Medical Association (AMA)
Kellett, Sally& Cock, Charles. A Case of Drug Reaction with Eosinophilia and Systemic Symptoms. Case Reports in Medicine. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-491988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491988