Recent Trends in Multifunctional Liposomal Nanocarriers for Enhanced Tumor Targeting
Joint Authors
Perche, Federico
Torchilin, Vladimir P.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-32, 32 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-07
Country of Publication
Egypt
No. of Pages
32
Main Subjects
Abstract EN
Liposomes are delivery systems that have been used to formulate a vast variety of therapeutic and imaging agents for the past several decades.
They have significant advantages over their free forms in terms of pharmacokinetics, sensitivity for cancer diagnosis and therapeutic efficacy.
The multifactorial nature of cancer and the complex physiology of the tumor microenvironment require the development of multifunctional nanocarriers.
Multifunctional liposomal nanocarriers should combine long blood circulation to improve pharmacokinetics of the loaded agent and selective distribution to the tumor lesion relative to healthy tissues, remote-controlled or tumor stimuli-sensitive extravasation from blood at the tumor’s vicinity, internalization motifs to move from tumor bounds and/or tumor intercellular space to the cytoplasm of cancer cells for effective tumor cell killing.
This review will focus on current strategies used for cancer detection and therapy using liposomes with special attention to combination therapies.
American Psychological Association (APA)
Perche, Federico& Torchilin, Vladimir P.. 2013. Recent Trends in Multifunctional Liposomal Nanocarriers for Enhanced Tumor Targeting. Journal of Drug Delivery،Vol. 2013, no. 2013, pp.1-32.
https://search.emarefa.net/detail/BIM-491994
Modern Language Association (MLA)
Perche, Federico& Torchilin, Vladimir P.. Recent Trends in Multifunctional Liposomal Nanocarriers for Enhanced Tumor Targeting. Journal of Drug Delivery No. 2013 (2013), pp.1-32.
https://search.emarefa.net/detail/BIM-491994
American Medical Association (AMA)
Perche, Federico& Torchilin, Vladimir P.. Recent Trends in Multifunctional Liposomal Nanocarriers for Enhanced Tumor Targeting. Journal of Drug Delivery. 2013. Vol. 2013, no. 2013, pp.1-32.
https://search.emarefa.net/detail/BIM-491994
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491994