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Functions of BCL-XL at the Interface between Cell Death and Metabolism
Joint Authors
Senovilla, Laura
Castedo, Maria
Galluzzi, Lorenzo
Kroemer, Guido
Kepp, Oliver
Lissa, Delphine
Michels, Judith
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The BCL-2 homolog BCL-XL, one of the two protein products of BCL2L1, has originally been characterized for its prominent prosurvival functions.
Similar to BCL-2, BCL-XL binds to its multidomain proapoptotic counterparts BAX and BAK, hence preventing the formation of lethal pores in the mitochondrial outer membrane, as well as to multiple BH3-only proteins, thus interrupting apical proapoptotic signals.
In addition, BCL-XL has been suggested to exert cytoprotective functions by sequestering a cytosolic pool of the pro-apoptotic transcription factor p53 and by binding to the voltage-dependent anion channel 1 (VDAC1), thereby inhibiting the so-called mitochondrial permeability transition (MPT).
Thus, BCL-XL appears to play a prominent role in the regulation of multiple distinct types of cell death, including apoptosis and regulated necrosis.
More recently, great attention has been given to the cell death-unrelated functions of BCL-2-like proteins.
In particular, BCL-XL has been shown to modulate a number of pathophysiological processes, including—but not limited to—mitochondrial ATP synthesis, protein acetylation, autophagy and mitosis.
In this short review article, we will discuss the functions of BCL-XL at the interface between cell death and metabolism.
American Psychological Association (APA)
Michels, Judith& Kepp, Oliver& Senovilla, Laura& Lissa, Delphine& Castedo, Maria& Kroemer, Guido…[et al.]. 2013. Functions of BCL-XL at the Interface between Cell Death and Metabolism. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-491996
Modern Language Association (MLA)
Michels, Judith…[et al.]. Functions of BCL-XL at the Interface between Cell Death and Metabolism. International Journal of Cell Biology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-491996
American Medical Association (AMA)
Michels, Judith& Kepp, Oliver& Senovilla, Laura& Lissa, Delphine& Castedo, Maria& Kroemer, Guido…[et al.]. Functions of BCL-XL at the Interface between Cell Death and Metabolism. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-491996
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491996