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In Silico Docking of HNF-1a Receptor Ligands
Joint Authors
Devi, Tatavarthi Uma
Kaladhar, Dowluru SVGK
Sridhar, Gumpeny Ramachandra
Nageswara Rao, Padmanabhuni Venkata
Kumar, Sali Veeresh
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Background.
HNF-1a is a transcription factor that regulates glucose metabolism by expression in various tissues.
Aim.
To dock potential ligands of HNF-1a using docking software in silico.
Methods.
We performed in silico studies using HNF-1a protein 2GYP·pdb and the following softwares: ISIS/Draw 2.5SP4, ARGUSLAB 4.0.1, and HEX5.1.
Observations.
The docking distances (in angstrom units: 1 angstrom unit (Å) = 0.1 nanometer or 1 × 10−10 metres) with ligands in decreasing order are as follows: resveratrol (3.8 Å), aspirin (4.5 Å), stearic acid (4.9 Å), retinol (6.0 Å), nitrazepam (6.8 Å), ibuprofen (7.9 Å), azulfidine (9.0 Å), simvastatin (9.0 Å), elaidic acid (10.1 Å), and oleic acid (11.6 Å).
Conclusion.
HNF-1a domain interacted most closely with resveratrol and aspirin
American Psychological Association (APA)
Sridhar, Gumpeny Ramachandra& Nageswara Rao, Padmanabhuni Venkata& Kaladhar, Dowluru SVGK& Devi, Tatavarthi Uma& Kumar, Sali Veeresh. 2012. In Silico Docking of HNF-1a Receptor Ligands. Advances in Bioinformatics،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-492020
Modern Language Association (MLA)
Sridhar, Gumpeny Ramachandra…[et al.]. In Silico Docking of HNF-1a Receptor Ligands. Advances in Bioinformatics No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-492020
American Medical Association (AMA)
Sridhar, Gumpeny Ramachandra& Nageswara Rao, Padmanabhuni Venkata& Kaladhar, Dowluru SVGK& Devi, Tatavarthi Uma& Kumar, Sali Veeresh. In Silico Docking of HNF-1a Receptor Ligands. Advances in Bioinformatics. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-492020
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492020