MHC Class II Binding Prediction—A Little Help from a Friend
Joint Authors
Garnev, Panayot
Flower, Darren R.
Doytchinova, Irini
Dimitrov, Ivan
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Vaccines are the greatest single instrument of prophylaxis against infectious diseases, with immeasurable benefits to human wellbeing.
The accurate and reliable prediction of peptide-MHC binding is fundamental to the robust identification of T-cell epitopes and thus the successful design of peptide- and protein-based vaccines.
The prediction of MHC class II peptide binding has hitherto proved recalcitrant and refractory.
Here we illustrate the utility of existing computational tools for in silico prediction of peptides binding to class II MHCs.
Most of the methods, tested in the present study, detect more than the half of the true binders in the top 5% of all possible nonamers generated from one protein.
This number increases in the top 10% and 15% and then does not change significantly.
For the top 15% the identified binders approach 86%.
In terms of lab work this means 85% less expenditure on materials, labour and time.
We show that while existing caveats are well founded, nonetheless use of computational models of class II binding can still offer viable help to the work of the immunologist and vaccinologist.
American Psychological Association (APA)
Dimitrov, Ivan& Garnev, Panayot& Flower, Darren R.& Doytchinova, Irini. 2010. MHC Class II Binding Prediction—A Little Help from a Friend. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-492039
Modern Language Association (MLA)
Dimitrov, Ivan…[et al.]. MHC Class II Binding Prediction—A Little Help from a Friend. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-492039
American Medical Association (AMA)
Dimitrov, Ivan& Garnev, Panayot& Flower, Darren R.& Doytchinova, Irini. MHC Class II Binding Prediction—A Little Help from a Friend. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-492039
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492039