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Surgical Incision Induces Anxiety-Like Behavior and Amygdala Sensitization : Effects of Morphine and Gabapentin
Joint Authors
Li, Chang-Qi
Zhou, Xin-Fu
Zhang, Jian-Wei
Dai, Ru-Ping
Luo, Xue-Gang
Wang, Juan
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The role of affective dimension in the postoperative pain is still poorly understood.
The present study investigated the development of anxiety-like behavior and amygdala sensitization in incisional pain.
Using hind-paw incision model in rats, we showed that surgical incision induced the anxiety-like behavior as determined by elevated plus-maze and open-field tests.
Intraperitoneal (IP) morphine administration reversed mechanical allodynia and anxiety-like behavior in a dose-dependent manner.
Gabapentin also partially reduced incision-evoked mechanical allodynia and anxiety-like behavior in a dose-dependent manner.
After incision, the expression of phosphorylated cAMP response elements (CRE-) binding protein (p-CREB) was transiently upregulated in the central and basolateral nuclei in the bilateral amygdala.
The upregulation of p-CREB was inhibited by morphine and gabapentin.
The present study suggested that surgical incision could induce anxiety and amygdala sensitization that can be inhibited by morphine and gabapentin.
Thus treatment of surgery-induced affective disturbances by morphine and gabapentin may be a potential important adjunct therapy in the postoperative pain management.
American Psychological Association (APA)
Li, Chang-Qi& Zhang, Jian-Wei& Dai, Ru-Ping& Wang, Juan& Luo, Xue-Gang& Zhou, Xin-Fu. 2010. Surgical Incision Induces Anxiety-Like Behavior and Amygdala Sensitization : Effects of Morphine and Gabapentin. Pain Research and Treatment،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-492044
Modern Language Association (MLA)
Li, Chang-Qi…[et al.]. Surgical Incision Induces Anxiety-Like Behavior and Amygdala Sensitization : Effects of Morphine and Gabapentin. Pain Research and Treatment No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-492044
American Medical Association (AMA)
Li, Chang-Qi& Zhang, Jian-Wei& Dai, Ru-Ping& Wang, Juan& Luo, Xue-Gang& Zhou, Xin-Fu. Surgical Incision Induces Anxiety-Like Behavior and Amygdala Sensitization : Effects of Morphine and Gabapentin. Pain Research and Treatment. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-492044
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492044