Optimisation of a Generic Ionic Model of Cardiac Myocyte Electrical Activity
Joint Authors
Guo, Tianruo
Lovell, Nigel H.
Dokos, Socrates
al-Abed, Amr
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-02
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
A generic cardiomyocyte ionic model, whose complexity lies between a simple phenomenological formulation and a biophysically detailed ionic membrane current description, is presented.
The model provides a user-defined number of ionic currents, employing two-gate Hodgkin-Huxley type kinetics.
Its generic nature allows accurate reconstruction of action potential waveforms recorded experimentally from a range of cardiac myocytes.
Using a multiobjective optimisation approach, the generic ionic model was optimised to accurately reproduce multiple action potential waveforms recorded from central and peripheral sinoatrial nodes and right atrial and left atrial myocytes from rabbit cardiac tissue preparations, under different electrical stimulus protocols and pharmacological conditions.
When fitted simultaneously to multiple datasets, the time course of several physiologically realistic ionic currents could be reconstructed.
Model behaviours tend to be well identified when extra experimental information is incorporated into the optimisation.Erratum to “Optimisation of a Generic Ionic Model of Cardiac Myocyte Electrical Activity”dx.doi.org/10.1155/2013/213563
American Psychological Association (APA)
Guo, Tianruo& al-Abed, Amr& Lovell, Nigel H.& Dokos, Socrates. 2013. Optimisation of a Generic Ionic Model of Cardiac Myocyte Electrical Activity. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-492079
Modern Language Association (MLA)
Guo, Tianruo…[et al.]. Optimisation of a Generic Ionic Model of Cardiac Myocyte Electrical Activity. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-20.
https://search.emarefa.net/detail/BIM-492079
American Medical Association (AMA)
Guo, Tianruo& al-Abed, Amr& Lovell, Nigel H.& Dokos, Socrates. Optimisation of a Generic Ionic Model of Cardiac Myocyte Electrical Activity. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-492079
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492079