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Study of Leptin and Adiponectin as Disease Markers in Subjects with Obstructive Sleep Apnea
Joint Authors
al-Alawi, Alia
Abdella, Nabila
al-Mutairi, Sana
al-Rammah, Tahani
Mojiminiyi, Olusegun A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Published studies showed conflicting results of the associations between adiponectin and leptin levels and obstructive sleep apnoea (OSA).
In obese patients, plasma leptin is elevated and adiponectin is decreased, and we postulate that these adipokines could be potential markers of clinical and metabolic perturbations in patients with OSA.
Methods.
147 patients with suspected OSA had polysomnography to determine the Respiratory Disturbance Index (RDI).
We measured fasting plasma glucose (FPG), fasting serum insulin, plasma leptin, adiponectin, and full lipid profile.
Patients were classified on the basis of the RDI, degree of adiposity, and insulin resistance (IR) (homeostasis model assessment of insulin resistance (HOMAIR)).
Results.
28.6% of subjects had normal polysomnography, 34.8% had mild OSA, 19.6% had moderate OSA, and 17% had severe OSA.
Obesity was more prevalent in subjects with moderate-severe OSA (47%).
Adiponectin decreased significantly (P=0.041) with increasing severity of OSA.
Though BMI was significantly higher in subjects with severe OSA, paradoxically, leptin was lowest in those subjects independent of gender dimorphism.
Conclusions.
Adiponectin is an independent marker of disease severity in patients with OSA.
The paradoxical decrease in circulating leptin, which suggests impaired secretion, deserves further studies as a potential marker of severe OSA.
American Psychological Association (APA)
al-Mutairi, Sana& Mojiminiyi, Olusegun A.& al-Alawi, Alia& al-Rammah, Tahani& Abdella, Nabila. 2014. Study of Leptin and Adiponectin as Disease Markers in Subjects with Obstructive Sleep Apnea. Disease Markers،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-492092
Modern Language Association (MLA)
al-Mutairi, Sana…[et al.]. Study of Leptin and Adiponectin as Disease Markers in Subjects with Obstructive Sleep Apnea. Disease Markers No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-492092
American Medical Association (AMA)
al-Mutairi, Sana& Mojiminiyi, Olusegun A.& al-Alawi, Alia& al-Rammah, Tahani& Abdella, Nabila. Study of Leptin and Adiponectin as Disease Markers in Subjects with Obstructive Sleep Apnea. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-492092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492092