The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X4 Receptors
Joint Authors
Huidobro-Toro, J. Pablo
Lorca, Ramón A.
Varela-Nallar, Lorena
Inestrosa, Nibaldo C.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Although the physiological function of the cellular prion protein (PrPC) remains unknown, several evidences support the notion of its role in copper homeostasis.
PrPC binds Cu2+ through a domain composed by four to five repeats of eight amino acids.
Previously, we have shown that the perfusion of this domain prevents and reverses the inhibition by Cu2+ of the adenosine triphosphate (ATP)-evoked currents in the P2X4 receptor subtype, highlighting a modulatory role for PrPC in synaptic transmission through regulation of Cu2+ levels.
Here, we study the effect of full-length PrPC in Cu2+ inhibition of P2X4 receptor when both are coexpressed.
PrPC expression does not significantly change the ATP concentration-response curve in oocytes expressing P2X4 receptors.
However, the presence of PrPC reduces the inhibition by Cu2+ of the ATP-elicited currents in these oocytes, confirming our previous observations with the Cu2+ binding domain.
Thus, our observations suggest a role for PrPC in modulating synaptic activity through binding of extracellular Cu2+.
American Psychological Association (APA)
Lorca, Ramón A.& Varela-Nallar, Lorena& Inestrosa, Nibaldo C.& Huidobro-Toro, J. Pablo. 2011. The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X4 Receptors. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-492111
Modern Language Association (MLA)
Lorca, Ramón A.…[et al.]. The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X4 Receptors. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-492111
American Medical Association (AMA)
Lorca, Ramón A.& Varela-Nallar, Lorena& Inestrosa, Nibaldo C.& Huidobro-Toro, J. Pablo. The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X4 Receptors. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-492111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492111