The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X4 Receptors

Joint Authors

Huidobro-Toro, J. Pablo
Lorca, Ramón A.
Varela-Nallar, Lorena
Inestrosa, Nibaldo C.

Source

International Journal of Alzheimer's Disease

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-10-19

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Diseases
Medicine

Abstract EN

Although the physiological function of the cellular prion protein (PrPC) remains unknown, several evidences support the notion of its role in copper homeostasis.

PrPC binds Cu2+ through a domain composed by four to five repeats of eight amino acids.

Previously, we have shown that the perfusion of this domain prevents and reverses the inhibition by Cu2+ of the adenosine triphosphate (ATP)-evoked currents in the P2X4 receptor subtype, highlighting a modulatory role for PrPC in synaptic transmission through regulation of Cu2+ levels.

Here, we study the effect of full-length PrPC in Cu2+ inhibition of P2X4 receptor when both are coexpressed.

PrPC expression does not significantly change the ATP concentration-response curve in oocytes expressing P2X4 receptors.

However, the presence of PrPC reduces the inhibition by Cu2+ of the ATP-elicited currents in these oocytes, confirming our previous observations with the Cu2+ binding domain.

Thus, our observations suggest a role for PrPC in modulating synaptic activity through binding of extracellular Cu2+.

American Psychological Association (APA)

Lorca, Ramón A.& Varela-Nallar, Lorena& Inestrosa, Nibaldo C.& Huidobro-Toro, J. Pablo. 2011. The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X4 Receptors. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-492111

Modern Language Association (MLA)

Lorca, Ramón A.…[et al.]. The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X4 Receptors. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-492111

American Medical Association (AMA)

Lorca, Ramón A.& Varela-Nallar, Lorena& Inestrosa, Nibaldo C.& Huidobro-Toro, J. Pablo. The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X4 Receptors. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-492111

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-492111