Broader Considerations of Higher Doses of Donepezil in the Treatment of Mild, Moderate, and Severe Alzheimer's Disease
Joint Authors
Sabbagh, Marwan N.
Berk, Camryn
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-01
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Donepezil, a highly selective acetylcholinesterase inhibitor (AChEI), is approved as a symptomatic treatment mild, moderate, and severe Alzheimer's disease (AD).
Donepezil exerts its treatment effect through multiple mechanisms of action including nicotinic receptor stimulation, mitigation of excitotoxicity, and influencing APP processing.
The use of donepezil at higher doses is justified given the worsening cholinergic deficit as the disease advances.
Donepezil has been investigated in several clinical trials of subjects with moderate-to-severe AD.
While the side effects are class specific (cholinergically driven), demonstrable benefit has been shown at the 10 mg dose and the 23 mg doses.
Here, we review the clinical justification, efficacy, safety, and tolerability of use of donepezil in the treatment of moderate-to-severe AD.
American Psychological Association (APA)
Berk, Camryn& Sabbagh, Marwan N.. 2011. Broader Considerations of Higher Doses of Donepezil in the Treatment of Mild, Moderate, and Severe Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-492179
Modern Language Association (MLA)
Berk, Camryn& Sabbagh, Marwan N.. Broader Considerations of Higher Doses of Donepezil in the Treatment of Mild, Moderate, and Severe Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-492179
American Medical Association (AMA)
Berk, Camryn& Sabbagh, Marwan N.. Broader Considerations of Higher Doses of Donepezil in the Treatment of Mild, Moderate, and Severe Alzheimer's Disease. International Journal of Alzheimer's Disease. 2011. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-492179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492179